Speeding up MS imaging with fast mirror scanning

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Authors	BEDNAŘÍK Antonín KUBA Pavel HOUŠKA Pavel TOMALOVÁ Iva MOSKOVETS Eugene PREISLER Jan
Year of publication	2012
Type	Conference abstract
MU Faculty or unit	Central European Institute of Technology
Citation
Description	High resolution mass spectrometry imaging (MSI) analysis may involve mass spectra recording from 10 000 or more measurement points. Though a new generation of mass spectrometers with kHz lasers brought significant decrease of MSI time, one image acquisition can still consume many hours. In such a device utilizing high repetition laser the total imaging time is no longer limited only by the data acquisition but also by the speed of the target stage translation. With a proper design of ion source optics, speeding up of the MSI can be achieved by substitution of the stage translation with a fast scanning mirror redirecting the desorption laser beam in micrometer scale. A prototype with 2 kHz 355 nm Nd:YAG laser and the fast precision scanning mirror was used to record 10 000 pixel MS map with 100 acquisitions per pixel in 12,5 minutes, an order of magnitude faster compared to the commercial instrument, 1 kHz AutoFlexTM Speed (Bruker Daltonics).
Related projects:	Analýza biomolekul hmotnostní spektrometrií s laserovou desorpcí/ionizací za účasti nanomateriálů CEITEC - Central European Institute of Technology