Type 2 Cannabinoid Receptor Protein and mRNA Expression in Dorsal Column Nuclei of Two Rat Neuropathic Pain Models

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Authors	HRADILOVÁ SVÍŽENSKÁ Ivana KLUSÁKOVÁ Ilona BRÁZDA Václav DUBOVÝ Petr
Year of publication	2012
Type	Conference abstract
MU Faculty or unit	Central European Institute of Technology
Citation
Description	CB2R activation inhibits pain responses without adverse, most often psychotropic effects that are produced by CB1R agonists. The aim of this study was to examine the dorsal column nuclei for CB2R expression following peripheral nerve injury and to explore a possibility of its contribution to neuropathic pain. Using immunohistochemistry and in situ hybridization in two rat neuropathic pain models, sciatic nerve chronic constriction injury (CCI) and spared nerve injury (SNI), we investigated CB2R synthesis and protein distribution in the dorsal column nuclei.Our results demonstrate that expression of CB2 receptors coincides with hyperactivity of medullary microglia what may contribute to the pathogenesis of neuropathic pain.
Related projects:	CEITEC - Central European Institute of Technology