Molekulární genetika Alzheimerovy choroby – cesta k personalizované diagnostice a léčbě
| Title in English | Molecular genetics of Alzheimer's disease - the pathway to personalized diagnostics and treatment |
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| Authors | |
| Year of publication | 2013 |
| MU Faculty or unit | |
| Citation | |
| Description | Findings about molecular basis of Alzheimer's disease expanded in recent years due to possibilities of new microarray technology and 2nd generation sequencing. There have been proved correlation of number of genes with AD pathogenesis. New theories have been introduced explaining this AD pathogenesis. Abeta cleaving pathways have been thoroughly described also with the possibility of pharmacological impact. Mitochondrial trafficking in cell, microvascular bleeding are thought to be involved in AD development. One of the most recent theories of AD development suggest the involvement non-coding micro RNA (miRNA) in the concentration changes of proteases cleaving Abeta. Despite this there still remains the evidence of apolipoprotein E genotypes to be crucial in czech population.Use of microarray technology for systematical studying of epidemiological data, familial and personal anamnesis of those individuals having AD willl hopefuly allow in following years more personalized diagnotics and treatmant. |
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