Vliv repetitivní transkraniální magnetické stimulace na nikotinismus u schizofrenie: otevřená studie
| Title in English | Effect of repetitive transcranial magnetic stimulation on nicotine smoking in schizophrenia: Open study |
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| Authors | |
| Year of publication | 2013 |
| Type | Article in Periodical |
| Magazine / Source | Česká a slovenská psychiatrie |
| MU Faculty or unit | |
| Citation | |
| Field | Psychiatry, sexuology |
| Keywords | Nicotine; Repetitive transcranial magnetic stimulation; RTMS; Schizophrenia; Smoking |
| Attached files | |
| Description | The prevalence of nicotine cigarettes smoking in schizophrenia patients is estimated in a range between 45 to 88%. High-frequency repetitive transcranial magnetic stimulation (rTMS) over the left dorsolateral prefrontal cortex (DLPFC) decreased tobacco consumption and craving in nicotine dependent people. However rTMS has not been used in this indication in schizophrenia patients. The aim of the study: The aim of our study was to proved if high-frequency (10Hz) rTMS over the left DLPFC is able to decrease nicotine cigarettes consumption in schizophrenia patients. Methods: There were 18 male schizophrenia patients on stable antipsychotic medication included to the study. The actual performance of rTMS was defined by the application location (left dorsolateral prefrontal cortex: DLPFC), intensity of magnetic stimulation in % of motor threshold (110%), stimulation frequency (10Hz), number of trains (20), single train duration (10s), intertrain interval (30s), and total number of stimulation sessions (15). Thus in each stimulation session 2 000 TMS pulses were given, with a total of 30 000 pulses per treatment course. Patients wrote number of smoked nicotine cigarettes seven days before and during whole stimulation treatment (21 days). Results: Nicotine cigarettes consumption was statistically significantly decreasing during stimulation treatment. It was evident from the second week of stimulation. There were found no statistically relevant correlations between the ongoing changes of negative and depressive schizophrenia symptoms and number smoked nicotine cigarettes. Conclusion: The high-frequency rTMS over the left DLPFC has got a potential to decrease number of smoked nicotine cigarettes in schizophrenia patients. |
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