THE STUDY OF DNA HEPTAMERS WITH DIFFERENT TRINUCLEOTIDE SEQUENCES IN A LOOP BY ELECTROCHEMICAL AND SPECTRAL METHODS

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Authors

PILAŘOVÁ Iveta BALCAROVÁ Zdeňka TRNKOVÁ Libuše

Year of publication 2013
Type Article in Proceedings
Conference XIII. Pracovní setkání fyzikálních chemiků a elektrochemiků, sborník
MU Faculty or unit

Faculty of Science

Citation
Field Electrochemistry
Keywords hairpins;DNA heptamers;hairpin loop;cyclic voltammetry;EVLS
Description Hairpins or hairpin-like structures consisting of a single-stranded loop region closed by a base-paired stem occur not only in single-stranded DNAs and RNAs but also in double-stranded DNAs. Hairpins as a basic unit of nucleic acid structure play a very important role in many biological processes, including the triplet repeat expansion associated with neurodegenerative diseases (fragile chromosome X syndrome, Huntington’s disease, myotonic dystrophy).
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