THE STUDY OF DNA HEPTAMERS WITH DIFFERENT TRINUCLEOTIDE SEQUENCES IN A LOOP BY ELECTROCHEMICAL AND SPECTRAL METHODS
| Authors | |
|---|---|
| Year of publication | 2013 |
| Type | Article in Proceedings |
| Conference | XIII. Pracovní setkání fyzikálních chemiků a elektrochemiků, sborník |
| MU Faculty or unit | |
| Citation | |
| Field | Electrochemistry |
| Keywords | hairpins;DNA heptamers;hairpin loop;cyclic voltammetry;EVLS |
| Description | Hairpins or hairpin-like structures consisting of a single-stranded loop region closed by a base-paired stem occur not only in single-stranded DNAs and RNAs but also in double-stranded DNAs. Hairpins as a basic unit of nucleic acid structure play a very important role in many biological processes, including the triplet repeat expansion associated with neurodegenerative diseases (fragile chromosome X syndrome, Huntington’s disease, myotonic dystrophy). |
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