Urine microRNAs as potential noninvasive biomarkers in urologic cancers?

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Authors

MLČOCHOVÁ Hana HÉŽOVÁ Renata STANÍK Michal SLABÝ Ondřej

Year of publication 2014
Type Article in Periodical
Magazine / Source UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
MU Faculty or unit

Central European Institute of Technology

Citation
Web http://www.sciencedirect.com/science/article/pii/S107814391300197X
Doi http://dx.doi.org/10.1016/j.urolonc.2013.04.011
Field Oncology and hematology
Keywords MicroRNA; Diagnosis; Biomarker; Urologic cancer; Urothelial cancer; Bladder cancer; Prostate cancer; Renal cell carcinoma
Description Micro-ribonucleic acids (miRNAs) are small noncoding RNAs that posttranscriptionally regulate gene expression. The ability of miRNAs to inhibit translation of oncogenes and tumor suppressors implies that they may be involved in carcinogenesis. Our review focuses on the potential of urinary miRNAs to serve as biomarkers of urologic cancers. We discuss in detail the recent knowledge about the origin of urinary miRNAs, their stability, quality control, and their utility as a potential new class of biomarkers in urologic cancer. Finally, we summarize the studies focusing on detection and characterization of urinary miRNAs as potential biomarkers in bladder, prostate, and kidney cancers.
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