Kinetic characterization of cytochrome P450 2C9 hydroxylation of diclofenac by capillary electrophoresis – mass spectrometry
| Authors | |
|---|---|
| Year of publication | 2013 |
| Type | Article in Periodical |
| Magazine / Source | Chemické listy |
| MU Faculty or unit | |
| Citation | |
| Web | http://www.chemicke-listy.cz/common/content-issue_s3-volume_107-year_2013.html |
| Field | Biochemistry |
| Keywords | capillary electrophoresis; mass spectrometry; on-line connection; enzyme reaction |
| Attached files | |
| Description | Subject of this contribution is application of capillary electrophoresis – mass spectrometry for kinetic characterization of cytochrome P450 2C9 hydroxylation of diclofenac. In this study enzymatic reaction was took place inside the capillary, resulting compounds were detected by MS. Mixing of reaction components in capillary was based on the general principle of diffusion. |
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