Therapeutic Dendritic Cell-Based Cancer Vaccines: The State of the Art

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Authors

STRIOGA Marius FELZMANN Thomas POWELL Daniel J. Jr. OSTAPENKO Valerijus DOBROVOLSKIENE Neringa T. MATÚŠKOVÁ Miroslava MICHÁLEK Jaroslav SCHIJNS Virgil

Year of publication 2013
Type Article in Periodical
Magazine / Source CRITICAL REVIEWS IN IMMUNOLOGY
MU Faculty or unit

Faculty of Medicine

Citation
Doi http://dx.doi.org/10.1615/CritRevImmunol.2013008033
Field Immunology
Keywords dendritic cells; therapeutic cancer vaccines; maturation cocktails; polarizing signal; homing signal
Description Dendritic cells (DCs) are the most potent professional antigen-presenting cells, capable of initiating proper adaptive immune responses. Although tumor-infiltrating DCs are able to recognize cancer cells and uptake tumor antigens, they often have impaired functions because of the immunosuppressive tumor milieu. Therefore, DCs are targeted by therapeutic means either in vivo or ex vivo to facilitate tumor antigen presentation to T cells and induce or promote efficient antitumor immune responses in cancer patients. This immunotherapeutical approach is defined as specific active tumor immunotherapy or therapeutic cancer vaccination. In this review we briefly discuss general aspects of DC biology, followed by a thorough description of the current knowledge and optimization trends of DC vaccine production ex vivo, including various approaches for the induction of proper DC maturation and efficient loading with tumor antigens. We also discuss critical clinical aspects of DC vaccine application in cancer patients, including protocols of administration (routes and regimens), individualization of tumor immunotherapy, prediction and proper evaluation of immune and clinical responses to immunotherapy, and the critical role of combining tumor immunotherapy with other cancer treatment strategies to achieve maximal therapeutic effects.
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