Bioactive molecules of the blood-feeding monogenean Eudiplozoon nipponicum
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| Year of publication | 2013 |
| Type | Conference abstract |
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| Description | Monogeneans of the family Diplozoidae are ectoparasitic blood-feeders inhabiting the gills of cyprinid fish. They can be significantly virulent to their hosts, causing mechanical damage to gill filaments accompanied by a risk of secondary bacterial and mycotic infections or anemia. In contrast to other blood-feeding parasites, the host-parasite "communication" at the molecular level is among monogeneans largely unknown. We performed the first insights into molecular biology of diplozoid parasites by exploring the transcriptome of the adult stage of Eudiplozoon nipponicum (group Heteronchoinea), using 454 sequencing technology (GS FLX System, ROCHE). We are primarily focused on identification and characterization of selected molecules involved in host-parasite interaction. Special attention is paid to molecules participating on digestion of host's blood (e.g. proteolytic enzymes - peptidases) and other molecules (e.g. anticoagulants) playing essential role in biological processes in the parasite. |
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