Involvement of region-specific HRF in classical analysis of event-related fMRI data

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Authors

BARTOŇ Marek MIKL Michal MAREČEK Radek HAVLÍČEK Martin

Year of publication 2012
Type Article in Proceedings
Conference Systems, Signals and Image Processing (IWSSIP), 2012 19th International Conference on
MU Faculty or unit

Central European Institute of Technology

Citation
Web http://ieeexplore.ieee.org/xpl/articleDetails.jsp?tp=&arnumber=6208187&queryText%3Dbarton+m+2012
Field Neurology, neurosurgery, neurosciences
Keywords fMRI; hemodynamic response; HRF estimation; canonical temporal and disperse derivatives; FIR; B-spline; mFIR
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Description The shape of hemodynamic response function (HRF) as it is measured by fMRI is influenced by many factors. Even the time course of neuronal activity by itself does not necessarily trace the time course of fMRI experimental stimulation. The analysis of fMRI data based on assumption of commonly considered (fixed) HRF shape may therefore be mismatched due to inaccurate modeling. Therefore, to formulate more accurate models, by using estimated region-specific HRF for particular volume elements of the brain, may be beneficial. The aim of this paper is to verify the methodology, which involves HRF estimations, in comparison to the classical form of fMRI data analysis. For estimations of HRF was chosen regression method with a modified set of FIR basis functions.
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