Cytokinové profily mnohočetného myelomu a Waldenströmovy makroglobulinemie

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Title in English Cytokine profiles of multiple myeloma and waldenström macroglobulinemia
Authors

SEDLAŘÍKOVÁ Lenka SADÍLKOVÁ Kateřina KUBICZKOVÁ Lenka HÁJEK Roman ŠEVČÍKOVÁ Sabina

Year of publication 2014
Type Article in Periodical
Magazine / Source Klinická onkologie
MU Faculty or unit

Faculty of Medicine

Citation
Web http://www.linkos.cz/files/klinicka-onkologie/183/4381.pdf
Field Oncology and hematology
Keywords Bone marrow microenvironment; Cytokines; Multiple myeloma; Waldenström macroglobulinemia
Description Multiple myeloma (MM) and Waldenström macroglobulinemia (WM) are malignant disorders of B lymphocytes. These diseases are characterized by monoclonal immunoglobulin production and bone marrow infiltration, which further lead to disease manifestation mainly via osteolytic lesions and disruption of hematopoiesis. The bone marrow microenvironment plays a crucial role in pathogenesis of both of these diseases, as it is well known that interaction between malignant cells and bone marrow cells facilitates both survival and growth of these tumor cells. The interactions are mediated by several different factors, including cytokines. Their production leads to tumor cell growth, proliferation and survival contributing to pathogenesis of MM and WM. In this review, we focus on function of the most important cytokines in both these diseases.
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