The role of c-Myb in survival signaling pathways of colorectal carcinoma cells

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Authors

PEKARČÍKOVÁ Lucie KNOPFOVÁ Lucia ŠMARDA Jan

Year of publication 2014
Type Conference abstract
MU Faculty or unit

Faculty of Science

Citation
Description Colorectal carcinoma (CRC) is the third most common cancer in the world and is one of the leading causes of cancer-related deaths. The c-Myb is transcription factor playing essential role in control of proliferation, differentiation and apoptosis of epithelial cells. c-Myb overexpression in CRC is known to be a prognostic indicator for poor survival of patients. The aim of this study was to clarify the role of c-Myb in control of death/survival of CRC cells. We showed that the c-Myb protein reduced sensitivity of these cells to the cytostatic agens. We found that fraction of CRC cells with depolarized mitochondrial membrane decreases upon expression of c-Myb. Mitochondria are a major site of production of reactive oxygen species that play important role in regulation of cell survival. We tested the level of reactive oxygen species and expression/activity of key components of several signaling pathways in c-Myb-expressing cells to identify the downstream effectors mediating the effects of c-Myb on cell viability. In this work, we describe a novel c-Myb-p38?/JNK signal axis mediating increased resistance of colorectal cells to cytotoxic agents and discuss the role of reactive oxygen species in these signaling pathways.
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