On initial ion velocities in MALDI: A novel FT-ICR MS approach

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Authors

TOMALOVÁ Iva FRANKEVICH Vladimir ZENOBI Renato

Year of publication 2014
Type Article in Periodical
Magazine / Source International Journal of Mass Spectrometry
MU Faculty or unit

Faculty of Science

Citation
Doi http://dx.doi.org/10.1016/j.ijms.2014.08.004
Field Analytic chemistry
Keywords FT-ICR MS; MALDI MS; initial ion velocities
Description Even after more than two decades of investigation, the question whether the initial velocity of ions generated by matrix-assisted laser desorption/ionization (MALDI) depends on their molecular weight or not remains unanswered. A novel method employing an internal MALDI source Fourier-transform ion cyclotron resonance mass spectrometry is used to measure the initial ion velocities of peptides with m/z values in the range of typical proteomic experiments. Simultaneous measurement of multiple matrix and analyte ions clearly shows initial ion velocities that depend on analyte or matrix molecular weight. The measured velocity values agree well with the published data.
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