Coupling of single HPLC separation run to ESI, MALDI and SALD ICP MS for metallothionein characterization

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Authors	POLANSKÝ Ondřej JÄGEROVÁ Kateřina TOMALOVÁ Iva DLABKOVÁ Kristýna KANICKÝ Viktor PREISLER Jan
Year of publication	2014
Type	Appeared in Conference without Proceedings
MU Faculty or unit	Central European Institute of Technology
Citation
Description	Metalloproteins account for nearly a half of all proteins in the nature; the metal-binding sites are often responsible for catalysis in important biological processes. Recently, we introduced the off-line coupling of capillary electrophoresis (CE) to both matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS) and substrate-assisted laser desorption inductively coupled plasma (SALD ICP) MS. Here we demonstrate the coupling of high performance liquid chromatography (HPLC) to three complementary detection systems, MALDI MS, electrospray ionization (ESI) MS and SALD ICP MS.
Related projects:	CEITEC - Central European Institute of Technology Nové strategie úpravy vzorků pro desorpční hmotnostní spektrometrii Zaměstnáním čerstvých absolventů doktorského studia k vědecké excelenci