Metabolic syndrome – dysregulation of adipose tissue endocrine function

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Authors

HORSKÁ Kateřina KUČEROVÁ Jana SUCHÝ Pavel KOTOLOVÁ Hana

Year of publication 2014
Type Article in Periodical
Magazine / Source Česká a slovenská farmacie
MU Faculty or unit

Faculty of Medicine

Citation
Web https://www.prolekare.cz/en/journals/czech-and-slovak-pharmacy/2014-4-3/metabolic-syndrome-dysregulation-of-adipose-tissue-endocrine-function-49586
Field Pharmacology and pharmaceutical chemistry
Keywords metabolic syndrome; insulin resistance; adipose tissue; adipokines
Description Metabolic syndrome, a condition increasing cardiovascular morbidity, mortality and risk for diabetes mellitus type 2, is currently worldwide reaching epidemic proportions. This complex disorder represents an urgent challenge for new pharmacotherapeutic strategies formulation. Pathophysiological mechanisms underlying metabolic syndrome are not completely understood, nevertheless growing evidence is supporting the hypothesis that multiple metabolic dysregulations do contribute to its development. A potential target for pharmacological intervention is considered to be dysregulation of adipose tissue endocrine/paracrine function. Specific adipokines, proteins secreted by the adipose tissue, with some pleiotropic effects, have been identified with strong association to regulation of energy metabolism, appetite, insulin signaling, tissue insulin sensitivity and the proinflammatory state related to metabolic syndrome. The aim of this paper is to provide a brief overview of endocrine/paracrine functions of the adipose tissue with regard to metabolic syndrome development and pathophysiology and particular adipokines as potential targets for innovative pharmacotherapeutic approaches.
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