Determination of binding constant of 1st generation antidiabetic drug with human serum albumin
| Authors | |
|---|---|
| Year of publication | 2014 |
| Type | Article in Proceedings |
| Conference | 11 th International Interdisciplinary Meeting on Bioanalysis CECE 2014 |
| MU Faculty or unit | |
| Citation | |
| Web | Oficiální stránky konference |
| Field | Biochemistry |
| Keywords | capillary electrophoresis - frontal analysis; 1st generation anitiabetic drugs; HSA |
| Description | The capillary electrophoresis fontal analysis (CE-FA) was used to study the affinities between selected 1st generation antidiabetic drugs (tolbutamide, chlorpropamide) and human serum albumin (HSA). The binding constant (Kb) was measured under physiological conditions. The log Kb values obtained by means of CE-FA have a good repeatability (RSD < 3%). |
| Related projects: |