Determination of binding constants of selected sulfonylureas drugs

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Authors	MICHALCOVÁ Lenka GLATZ Zdeněk
Year of publication	2014
Type	Conference abstract
MU Faculty or unit	Faculty of Science
Citation
Description	The strength of the interaction has a significant effect on biological activity of the drug. Various sulfonylureas (antidiabetic drugs) may induce hypoglycemia as a result of excesses in insulin production and release. Therefore, it is important to understand in detail the pharmacokinetics and pharmacodynamics of these drugs. The main objectives of this study were to determine the binding constants of the selected sulfonylurea drug (tolbutamide, chlorpropamide) with HSA using capillary electrophoresis – in physiological conditions.
Related projects:	Capillary electrophoresis as a member of the metabolomic analytical toolbox Centrum pokročilých bioanalytických technologií