Polymorphism 140A/G in lactotransferrin gene and its association with development of dental caries and gingivitis in children

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Authors

BARTOŠOVÁ Michaela BOŘILOVÁ LINHARTOVÁ Petra TREFNÁ Tereza VLAŽNÝ Jan MUSILOVÁ Kristína KUKLETOVÁ Martina KUKLA Lubomír IZAKOVIČOVÁ HOLLÁ Lydie

Year of publication 2014
Type Conference abstract
MU Faculty or unit

Faculty of Medicine

Citation
Description Introduction: Dental caries and periodontal diseases are complex, multifactorial diseases and one of the most common illnesses worldwide. Recent evidence suggests a role of LTF in caries and periodontitis. The aim of this study was determine the frequency of the polymorphism 140A/G in lactotransferrin gene and its association with dental caries and gingivitis in children in Czech population. Material and Methods: School children aged 11 – 13 years were included in the study (N = 637). The subjects were divided into two groups: without caries (DMFT = 0) and with caries (DMFT1). The caries affected group was stratified as low (DMFT=1), moderate (2DMFT3) and high (DMFT4) caries experience. The level of gingivitis was rated according to gingival index (GI) and subjects were divided into the groups without (GI = 0) and with (GI1) gingivitis. The LTF rs1126478 (140A/G exon 2, Lys/Arg) genotypes were determined by polymerase-chain reaction (PCR) with restriction analysis by EarI enzyme. Results: Of 637 subjects, 155 (24.3%) were caries free children. There were no statistical significant differences between caries levels and allele or genotype distributions in the total cohort. When the caries affected group (N=482) was stratified as low (DMFT=1), moderate (2DMFT3) and high (DMFT4) caries experience, allele and genotype frequencies were similar among all subgroups. Gingivitis was diagnosed in 53.4% children. The difference in frequencies of alleles and genotypes between the group of healthy children and children with gingivitis was also not significant (p0.05). Conclusion: The polymorphism 140A/G in lactotransferrin gene was not associated with the susceptibility and severity of dental caries and gingivitis in the Czech population.
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