Application of capillary electrophoresis hyphenated to mass spectrometry to protein – drug interaction study.

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Authors

LANGMAJEROVÁ Monika MICHALCOVÁ Lenka GLATZ Zdeněk

Year of publication 2014
Type Conference abstract
Citation
Description In this study binding constants for interaction between anti-diabetic agent glimepiride and human serum albumin were determined by capillary electrophoresis mass spectrometry in frontal analysis mode. This approach provides analyses under near-physiological condition and it is well suited for measurement of binding constant. Glimepiride is poorly soluble drug and belongs to third generation sulfonylurea used for treatment of diabetes mellitus type 2.
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