Combination of serum microRNA-320a and microRNA-320b as a marker for Waldenström macroglobulinemia

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Authors

BEŠŠE Lenka SEDLAŘÍKOVÁ Lenka KRYUKOV Fedor NEKVINDOVA Jana RADOVÁ Lenka ALMAŠI Martina PELCOVA Jana MINARIK Jiri PIKA Tomas PIKALOVA Zuzana SCUDLA Vlastimil KREJČÍ Marta ADAM Zdeněk POUR Luděk HÁJEK Roman ŠEVČÍKOVÁ Sabina

Year of publication 2015
Type Article in Periodical
Magazine / Source American Journal of Hematology
MU Faculty or unit

Faculty of Medicine

Citation
Doi http://dx.doi.org/10.1002/ajh.23910
Field Oncology and hematology
Keywords microRNA-320a; microRNA-320b; Waldenström macroglobulinemia
Attached files
Description IgM monoclonal gammopathies are a group of diseases characterized by increased level of IgM immunoglobulin produced by one clone of B cells. These diseases range trom benign (monoclonal gammopathy ot undetermined significance, MGUS) to malignant, such as Waldenstrom macroglobulinemia (WM) or to a lesser extent multiple myeloma (MM) [1,2]. The criteria that differentiate WM from IgM-MGUS are based on the extent of bone marrow (BM) involvement, amount of serum concentration of the M-proicin, presence or absence of symptomatic disease or more recently, MYD88 (L265P) or CXCR4 mutations [3-6]. Despite that, new criteria for the differential diagnosis between these conditions are still needed, circulating microRNAs (miRNAs) being one of them. Circulating miRNAs are present in different body fluids; they reflect physiological or pathologi cal conditions and can be used tor patient classification [7,8]. Thus, we aimed to investigate the ability of serum miRNAs to distinguish WM from IgM-MGUS as well as IgM-MM patients and healthy donors (HD).
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