Structural Biology in Use : NMR, X-ray and Molecular Dynamics Modeling in Study on Multistep Phosphorelay Signaling in Plants

• Authors: DEGTJARIK Oksana; DOPITOVÁ Radka; PEKÁROVÁ Blanka; KLUMPLER Tomáš; HORÁK Jakub; BORKOVCOVÁ Petra; NEJEDLÁ Eliška; ŘEHA David; PUEHRINGER Sandra; OTRUSINOVÁ Olga; JANSEN Séverine; KUTÝ Michal; WEISS Manfred S.; SKLENÁŘ Vladimír; MAREK Jaromír; PAPOUŠKOVÁ Veronika; ŽÍDEK Lukáš; KUTÁ-SMATANOVÁ Ivana; JANDA Lubomír; HEJÁTKO Jan
• Year of publication: 2014
• Type: Article in Proceedings
• Conference: 6. Metodické dny
• MU Faculty or unit: Central European Institute of Technology
• Web: http://wwwueb.asuch.cas.cz/methods/files/Methods_2014/Sbornik_Methods_2014_web_komplet.pdf
• Field: Botany
• Description: In multistep phosphorelay (MSP) pathway, the His-containing phosphotransmitters encoded by AHP genes in Arabidopsis act as signaling intermediates integrating signaling inputs from diverse sensor histidine kinases In comparison to prototypical two-component signaling in bacteria displaying high level of specificity, the level of specificity in related plant MSP signaling remained unclear Here I will describe our results employing both experimental and computational approaches in the identification of structural determinants of specificity in MSP signaling in Arabidopsis

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