Analysis of B-Cell Subpopulations in Monoclonal Gammopathies
| Authors | |
|---|---|
| Year of publication | 2015 |
| Type | Article in Periodical |
| Magazine / Source | Clinical Lymphoma Myeloma & Leukemia |
| MU Faculty or unit | |
| Citation | |
| Doi | http://dx.doi.org/10.1016/j.clml.2014.12.003 |
| Field | Oncology and hematology |
| Keywords | B-cell; Flow Cytometry; Multiple Myeloma; Monoclonal Gammopathy; Plasma Cell |
| Description | To clarify the pathophysiology of multiple myeloma (MM) it is necessary to investigate the various developmental stages of B-cells. We provide a detailed phenotypic profile and enumeration of B-cell subpopulations in monoclonal gammopathy patients. A reduction of B-cells and differentiation shift to more numerous antigenstimulated forms was observed in MM. This might indicate a potential source of myeloma-initiating cells in one of these subpopulations. |
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