The role of c-Myb in oxidative stress

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Authors

PEKARČÍKOVÁ Lucie KNOPFOVÁ Lucia ŠMARDA Jan

Year of publication 2015
Type Conference abstract
MU Faculty or unit

Faculty of Science

Citation
Description Colorectal carcinoma is the third most common cancer worldwide and is one of the leading causes of cancer-related deaths. c-Myb is a transcription factor playing essential role in control of proliferation, differentiation and apoptosis. c-Myb overexpression in colorectal cancer is known to be a prognostic indicator for poor prognosis of patients. In this work, we showed that c-Myb is significantly involved in pro-survival signalling pathways and we described a novel signal axis mediating decreased sensitivity of CRC cells to cytotoxic agents and documented for the first time that the prosurvival role of c-Myb is associated with deregulation of reactive oxygen species.
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