Successful renal transplantation in a patient with a Wiskott-Aldrich syndrome protein (WASP) gene mutation

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Authors

CHOVANCOVÁ Zita KUMAN M. VLKOVÁ Marcela LITZMAN Jiří

Year of publication 2015
Type Article in Periodical
Magazine / Source Transplant international
MU Faculty or unit

Faculty of Medicine

Citation
Doi http://dx.doi.org/10.1111/tri.12583
Field Surgery incl. transplantology
Keywords IgA nephropathy; immunodeficiency; renal transplantation; Wiskott-Aldrich syndrome
Description Wiskott-Aldrich syndrome (WAS) is a rare primary immunodeficiency disorder caused by mutations in the WAS protein (WASP) gene. Renal disease progressing to renal failure is a well-recognized complication in patients with WAS. Only a few case reports of renal transplantation have been reported to date. Here, we present a patient with a WASP mutation who suffered from severe atopic eczema, mild thrombocytopenia and only a slightly increased frequency of infections, who then developed IgA nephropathy and consequently underwent renal transplantation, which was successful. This study demonstrates that renal transplantation is possible in patients with WAS, regardless of conceivable complications.
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