Engraftment of acute and chronic myeloid leukemia in NOD scid gamma mice
| Authors | |
|---|---|
| Year of publication | 2015 |
| Type | Article in Periodical |
| Magazine / Source | Transfuze a hematologie dnes |
| MU Faculty or unit | |
| Citation | |
| Field | Oncology and hematology |
| Keywords | xenograft; NSG mouse; AML; CML |
| Description | The immunodeficient mouse represents an established animal model for leukemic transplantation studies. It is used both as a self-contained research tool for the study of leukemia genesis and progression, as well as for confirma¬tion of cell leukemogenic capability. The model as such has seen many modifications over the years, and while engraftment of primary acute and chronic myeloid leukemia samples is commonly feasible still not all samples can provide leukemic repopulation. This review specifically focuses on acute and chronic myeloid leukemia xe-nograft experiments using the current standard NOD.Cg-Prkdcxl° H2rg'm'w!'/SzJ mouse model and aims to provide a basic insight into the topic. It also discusses the various specifics relevant for conducting such experiments. |
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