Dextromethorphan as a Probe Drug for CYP2D6 and CYP3A4 Phenotyping
| Authors | |
|---|---|
| Year of publication | 2015 |
| Type | Chapter of a book |
| MU Faculty or unit | |
| Citation | |
| Description | Chapter summarizes the use of dextromethorphan as a marker substrate for CYP2D6 and CYP3A4 metabolic activity determination. The ratio of the concentration of the specific substrate to the metabolite(s) in various biological matrices (saliva, plasma/serum, urine) is the most widely used methodological approach to assess metabolic activity in vivo. |