Účinek etanolu na elektrickou aktivitu srdečních komorových buněk: experimentální a výpočtový přístup
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| Year of publication | 2015 |
| Type | Conference abstract |
| MU Faculty or unit | |
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| Description | In this study, we integrated the available (mostly animal) experimental data into previously published models of the rat and human ventricular myocyte to assess the share of ionic current components in ethanol-induced changes of AP configuration and cytosolic Ca2+ transient in ventricular cardiomyocytes. The rat model reproduced well the experimentally observed changes of AP duration (APD) under ethanol (slight prolongation at 0.8 mM and shortening at ?8 mM). These changes were almost exclusively caused by the ethanol-induced alterations of IK1. The cytosolic Ca2+ transient decreased gradually with the increasing ethanol concentration as a result of the ethanol-induced inhibition of ICa. In the human model, ethanol produced a dose-dependent APD lengthening, dominated by ethanol effect on IKr, the key repolarizing current in human ventricles. This effect might contribute to the clinically observed proarrhythmic effects of ethanol in predisposed individuals. |
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