Can Bioactive Compounds of Crocus sativus L. Influence the Metabolic Activity of Selected CYP Enzymes in the Rat?

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Authors

DOVRTĚLOVÁ Gabriela NOSKOVÁ Kristýna JUŘICA Jan TURJAP Miroslav ZENDULKA Ondřej

Year of publication 2015
Type Article in Periodical
Magazine / Source Physiological Research
MU Faculty or unit

Faculty of Medicine

Citation
Web http://www.biomed.cas.cz/physiolres/2015/S4_15.htm
Field Pharmacology and pharmaceutical chemistry
Keywords crocin; safranal; CYP; rat liver microsomes
Description The aim of the present study was to determine, whether systemic administration of safranal and crocin can influence the metabolic activity of CYP3A, CYP2C11, CYP2B, and CYP2A in rat liver microsomes (RLM). Our results demonstrate the ability of safranal and crocin to increase the total protein content and to change the metabolic activity of several CYP enzymes assessed as CYP specific hydroxylations of testosterone in RLM. Crocin significantly decreased the metabolic activity of all selected CYP enzymes, while safranal significantly increased the metabolic activity of CYP2B, CYP2C11 and CYP3A enzymes.
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