Některé aspekty účinnosti a snášenlivosti antidepresiv podstatné pro běžnou klinickou praxi
| Title in English | Some issues of antidepressant efficacy and tolerability relevant for routine clinical practice |
|---|---|
| Authors | |
| Year of publication | 2016 |
| Type | Article in Periodical |
| Magazine / Source | Psychiatrie pro praxi |
| MU Faculty or unit | |
| Citation | |
| Web | http://www.solen.cz/artkey/psy-201602-0003_Nektere_aspekty_ucinnosti_a_snasenlivosti_antidepresiv_podstatne_pro_beznou_klinickou_praxi.php?back=%2Fsearch.php%3Fquery%3D%2BPsychofarmakologie%2Bv%2Bonkologii%252C%2Bmo%25BEnosti%2Bovlivn%25ECn%25ED%2Bbolest |
| Field | Psychiatry, sexuology |
| Keywords | antidepressants; side effects; adherence; attitudes to treatment |
| Description | Current possibilities of available antidepressants (AD) are limited. In spite of great heterogeneity of depressive disorders, monoamines remain the main target of psychopharmacotherapy. The differences in treatment response are associated with genetic variability. The developing field of pharmacogenetics strives for individualized treatment; however, in routine clinical practice the choice of antidepressant is based on individual efficacy, tolerability and alignment of symptoms to a biochemical alteration. The presence of an adequate quantity of the active substance in CNS targets is undoubtedly a precondition for efficacy. This raises the issue of adherence. The most frequent reasons for non-adherence are insufficient efficacy, including residual symptoms, as well as side effects, particularly sexual dysfunction, and weight gain. Attitudes to treatment may also play a significant role. |
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