Common variants at PVT1, ATG13-AMBRA1, AHI1 and CLEC16A are associated with selective IgA deficiency
| Authors | |
|---|---|
| Year of publication | 2016 |
| Type | Article in Periodical |
| Magazine / Source | Nature Genetics |
| MU Faculty or unit | |
| Citation | |
| Doi | http://dx.doi.org/10.1038/ng.3675 |
| Field | Epidemiology, infectious diseases and clinical immunology |
| Keywords | Autoimmune diseases; Genome-wide association studies; Immunological deficiency syndromes |
| Attached files | |
| Description | Selective immunoglobulin A deficiency (IgAD) is the most common primary immunodeficiency in Europeans. Our genome-wide association study (GWAS) meta-analysis of 1,635 patients with IgAD and 4,852 controls identified four new significant (P < 5 × 10-8) loci and association with a rare IFIH1 variant (p.Ile923Val). |
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