STUDYING OF COMPETITIVE INTERACTIONS OF DRUGS WITH HUMAN SERUM ALBUMIN BY CAPILLARY ELECTROPHORESIS-FRONTAL ANALYSIS

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Authors	NEVÍDALOVÁ Hana MICHALCOVÁ Lenka GLATZ Zdeněk
Year of publication	2016
Type	Article in Proceedings
Conference	13 th International Interdisciplinary Meeting on Bioanalysis CECE 2016
MU Faculty or unit	Faculty of Science
Citation
web	Oficiální stránky konference
Field	Biochemistry
Keywords	capillary electrophoresis-frontal analysis; competitive interaction; albumin
Description	Drug-protein interactions have a significant effect on pharmacodynamics and pharmacokinetics properties of drugs. Bound fraction of drugs is reservoir, whereas free fraction provides pharmacological effect.Study of drug-protein interactions is thus important in the clinical therapy and in the development of new drugs.In this study displacement of L tryptophan from its binding site on human serum albumin (HSA) by several drugs was investigated by capillary electrophoresis frontal analysis (CE-FA).
Related projects:	Podpora biochemického výzkumu v roce 2016