Comparison of different methodologies – capillary electrophoresis - frontal analysis, equilibrium dialysis, circular dichroism and isothermal titration calorimetry for studying drug-protein interactions

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Authors

NEVÍDALOVÁ Hana MICHALCOVÁ Lenka GLATZ Zdeněk

Year of publication 2016
Type Conference abstract
MU Faculty or unit

Faculty of Science

Citation
Description Pharmacokinetics and pharmacodynamics behaviour of drug is influenced by its binding on human serum albumin. Therefore the evaluation of analytical methods for analysis of these interactions with a small amount of sample solution is a highly desirable.Integrating benefit of these methodologies is possibility to measure interaction of binding partners in their native states without immobilization or labelling under physiological conditions.
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