DESORPTION/IONIZATION MASS SPECTROMETRY WITH SILVER NANOPARTICLES IN LIPID ANALYSIS

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Authors

PILIAROVÁ Kristína ROBLOVÁ Vendula LÍSA Miroslav PREISLER Jan

Year of publication 2016
Type Article in Proceedings
Conference 13th International Interdisciplinary Meeting on Bioanalysis, CECE 2016
MU Faculty or unit

Faculty of Science

Citation
Field Analytic chemistry
Keywords RP-LC MS; SALDI; silver nanoparticles; lipids; plasma
Description This work aims at system optimization combining reversed phase liquid chromatography with on-line and off-line mass spectrometry detection. On-line detection was facilitated by APCI MS and off-line detection by SALDI MS using suspension of silver nanoparticles as matrix. Exploiting two different ionization mechanisms allowed obtaining complementary information from mass spectra of lipids. The application of the both techniques with high sensitivity and with low detection limits represents an alternative to GC-MS for analysis of nonpolar compounds.
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