High-Frequency Oscillations in the Human Anterior Nucleus of the Thalamus
| Authors | |
|---|---|
| Year of publication | 2016 |
| Type | Article in Periodical |
| Magazine / Source | BRAIN STIMULATION |
| MU Faculty or unit | |
| Citation | |
| web | http://ac.els-cdn.com/S1935861X16300602/1-s2.0-S1935861X16300602-main.pdf?_tid=c76ffb60-c2a3-11e6-8031-00000aab0f02&acdnat=1481792116_ea220e4e7b05fddf8710cc0e4c4f3e5b |
| Doi | http://dx.doi.org/10.1016/j.brs.2016.04.010 |
| Field | Neurology, neurosurgery, neurosciences |
| Keywords | ELECTRICAL-STIMULATION; EPILEPSY |
| Description | Deep brain stimulation of the anterior nucleus of the thalamus (ANT- DBS) has recently been introduced in therapy for refractory epilepsy and is approved for clinical use in Europe. ANT is a part of the Papez circuitry and is a key structure in the intrathalamic pathways; it also projects to the cingulate gyrus and further to the limbic structures and wide regions of the neocortex, and via the mammillary circuit to the brain stem. ANT stimulation produces EEG changes in the frontal and temporal areas and inhibits seizures. The role played by the ANT in human epileptic seizures and the mechanisms leading to the anti- seizure effects of ANT-DBS have not yet been fully elucidated. Knowledge of processes occurring in the ANT in human epilepsy might improve the understanding of its role. Here we report the first description of interictal and ictal EEG recording in the human ANT. |
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