Bezinterferonová léčba hepatitidy C

Warning

This publication doesn't include Faculty of Arts. It includes Faculty of Medicine. Official publication website can be found on muni.cz.

Title in English	Possibilities of IFN-free therapy of hepatitis C
Authors	HUSA Petr HUSA Petr
Year of publication	2016
Type	Article in Periodical
Magazine / Source	Interní medicína pro praxi
MU Faculty or unit	Faculty of Medicine
Citation
Field	Epidemiology, infectious diseases and clinical immunology
Keywords	chronic hepatitis C; sofosbuvir; ledipasvir; velpatasvir; paritaprevir; ombitasvir; dasabuvir; elbasvir; grazoprevir
Description	Chronic hepatitis C therapy using Directly Acting Antivirals (DAA) has high efficacy (till 100%), minimum contraindications and extraordinarily favorable safety profile. Primarily, it is necessary to pay attention to drug-drug interactions. However they are well documented and successfully resolvable already in general clinical practice. Current possibilities of interferon-free therapy represent combinations of sofosbuvir with other DAA or with ribavirin and combination of paritaprevir boosted by ritonavir + ombitasvir +- dasabuvir. Fixed combinaton of elbasvir and grazoprevir is already available in some countries of the world.