Enantioselective Synthesis of Cephalimysins B and C

Warning

This publication doesn't include Faculty of Arts. It includes Faculty of Science. Official publication website can be found on muni.cz.
Authors

CHALUPA David VOJÁČKOVÁ Petra PARTL Jiří PAVLOVIC Drazen NEČAS Marek ŠVENDA Jakub

Year of publication 2017
Type Article in Periodical
Magazine / Source Organic Letters
MU Faculty or unit

Faculty of Science

Citation
Web Full Text
Doi http://dx.doi.org/10.1021/acs.orglett.6b03373
Field Organic chemistry
Keywords ASYMMETRIC TOTAL-SYNTHESIS; PSEUROTIN-A; ABSOLUTE-CONFIGURATION; 1.3-DICARBONYL COMPOUNDS; ANGIOGENESIS INHIBITOR; ASPERGILLUS-FUMIGATUS; MICHAEL ADDITIONS; HYPEROLACTONE-C; AZASPIRENE; PRODUCT
Description The first synthesis of cephalimysins B and C is reported. The route features a Ni(II)-diamine-catalyzed enantioselective conjugate addition of a densely substituted 3(2H)-furanone and an efficient dihydroxylation-lactonization sequence as key steps in the assembly of the spirocyclic core. The fully synthetic strategy is amenable to analog preparation.
Related projects:

You are running an old browser version. We recommend updating your browser to its latest version.