Risperidone increases the cortical silent period in drug-naive patients with first-episode schizophrenia: A transcranial magnetic stimulation study

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Authors

USTOHAL Libor MAYEROVÁ Michaela HUBLOVÁ Veronika PŘIKRYLOVÁ KUČEROVÁ Hana ČEŠKOVÁ Eva KAŠPÁREK Tomáš

Type Article in Periodical
Magazine / Source Journal of Psychopharmacology
MU Faculty or unit

Central European Institute of Technology

Citation
Web http://journals.sagepub.com/doi/10.1177/0269881116662650
Doi http://dx.doi.org/10.1177/0269881116662650
Field Neurology, neurosurgery, neurosciences
Keywords Schizophrenia; cortical inhibition; cortical silent period; risperidone; transcranial magnetic stimulation
Description Objectives: Schizophrenia is accompanied by impaired cortical inhibition, as measured by several markers including the cortical silent period (CSP). It is thought that CSP measures gamma-aminobutyric acid receptors B (GABA(B)) mediated inhibitory activity. But the mutual roles of schizophrenia as a disease and the drugs used for the treatment of psychosis on GABA mediated neurotransmission are not clear. Methods: We recruited 13 drug-naive patients with first-episode schizophrenia. We used transcranial magnetic stimulation to assess CSP prior to initiating risperidone monotherapy and again four weeks later. At the same time, we rated the severity of psychopathology using the Positive and Negative Syndrome Scale (PANSS). Results: We obtained data from 12 patients who showed a significant increase in CSP, from 134.2041.81 ms to 162.95 +/- 61.98 ms (p=0.041; Cohen's d=0.544). After the treatment, the PANSS total score was significantly lower, as were the individual subscores (p<0.05). However, no correlation was found between CSP and PANSS. Conclusion: Our study in patients with first-episode schizophrenia demonstrated an association between risperidone monotherapy and an increase in GABA(B) mediated inhibitory neurotransmission.
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