Reduction of Doxorubicin-Induced Cardiotoxicity Using Nanocarriers: A Review

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Authors

FOJTŮ Michaela GUMULEC Jaromír STRAČINA Tibor RAUDENSKÁ Martina SKOTÁKOVÁ Anna VACULOVIČOVÁ Markéta ADAM Vojtech BABULA Petr NOVÁKOVÁ Marie MASAŘÍK Michal

Year of publication 2017
Type Article in Periodical
Magazine / Source Current Drug Metabolism
MU Faculty or unit

Faculty of Medicine

Citation
Doi http://dx.doi.org/10.2174/1389200218666170105165444
Field Biochemistry
Keywords Doxorubicin; nanoparticles; liposomal; polymeric; protein; gold; cardiotoxicity; nanocarriers
Description Background: Anthracycline antibiotic doxorubicin (DOX) is a very potent and extensively prescribed chemotherapeutic drug. It is widely utilized in the therapy of variety of haematological and solid tumours, although its administration is commonly accompanied with several severe side effects. The most serious one is a development of dose-dependent and cumulative cardiotoxicity. In the course of time, many strategies have been investigated in order to avoid or at least to diminish DOX-induced cardiac dysfunction; these include reduction of toxic effect by co-administration with iron chelators (dexrazoxane), trastuzumab, taxanes, statins, and ACE-inhibitors. However, the attenuation of cardiotoxic effect is still not satisfactory yet. Objective: This review represents an overall appraisal of studies concerning with the utilization of various doxorubicin-loaded nanoparticles in the cancer treatment with specific emphasis on those studies evaluating their influence on the reduction of heart tissue damage. Conclusion: Introduction of nanoscale drug delivery systems undoubtedly represents nowadays one of the most promising tools for lowering systemic toxicity. Nanoparticles enable to target the therapeutic payload directly towards the tumor tissue, thus leading to the increased accumulation of the drug in the desired tissue and simultaneously protecting surrounding healthy tissues.
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