The identification of combinatorial therapeutic approaches with BCR inhibitors in B cell malignancies

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Authors	PAVLASOVÁ Gabriela MUSILOVÁ Kateřina ŠEDA Václav ČERNÁ Kateřina VOJÁČKOVÁ Eva SVOBODOVÁ Veronika MRÁZ Marek
Year of publication	2017
Type	Conference abstract
MU Faculty or unit	Central European Institute of Technology
Citation
Description	It was shown that BCR inhibitors such as ibrutinib interrupt microenvironmental interactions and mobilize malignant B cells of chronic lymphocytic leukemia (CLL) from immune niches into the blood stream. It has been suggested that this mobilization will sensitize malignant B cells to other drugs, providing a possibility to introduce synthetically lethal combinations of drugs with an acceptable toxicity profile. This might be limited to a subgroup of CLL patients with specific underlying molecular mechanisms of disease biology or reaction to BCR inhibitors. The aim of this study was to test for the effect of ibrutinib on the expression of genes and activity of pathways that could be potentially targeted by clinically available drugs to achieve highly potent combinations.
Related projects:	CEITEC 2020