The effect of hydroxyapatite particle size on viscoelastic properties and calcium release from a thermosensitive triblock copolymer
| Authors | |
|---|---|
| Year of publication | 2017 |
| Type | Article in Periodical |
| Magazine / Source | COLLOID AND POLYMER SCIENCE |
| MU Faculty or unit | |
| Citation | |
| web | https://link.springer.com/article/10.1007%2Fs00396-016-3983-7 |
| Doi | http://dx.doi.org/10.1007/s00396-016-3983-7 |
| Keywords | Polymer composites; Smart polymers; Rheology; Hydroxyapatite; Core-shell particles; Sol-gel transition |
| Description | Well-defined "smart" injectable hydrogel based on hydrophilic poly(ethylene glycol) (PEG) and hydrophobic poly(lactic acid-co-glycolic acid) (PLA/PGA) copolymer (PLGA-PEG-PLGA) gelling at the body temperature was modified by bioactive hydroxyapatite (HAp) in the form of micro-, nano-, and core-shell particles (mu-HAp, n-HAp, and CS-x, respectively) to be applicable as calcium delivery system in bone regeneration. Viscoelastic moduli increased with HAp content as expected. Whereas systems containing mu-HAp or CS-x particles maintained two sol-gel and gel-sol phase transitions, the n-HAp containing system showed only one sol-gel phase transition due to the strong interactions between polymer chain and the n-HAp surface. In vitro, studies proved the controlled uniform release of calcium cations from both CS-x and n-HAp over the 9-day period without any initial burst release. |
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