Controlled photorelease of alkynoic acids and their decarboxylative deprotection for copper-catalyzed azide/alkyne cycloaddition
| Authors | |
|---|---|
| Year of publication | 2018 |
| Type | Article in Periodical |
| Magazine / Source | Chemical communications |
| MU Faculty or unit | |
| Citation | |
| Web | https://pubs.rsc.org/en/Content/ArticleLanding/2018/CC/C8CC03341B#!divAbstract |
| Doi | http://dx.doi.org/10.1039/c8cc03341b |
| Keywords | PHOTOREMOVABLE PROTECTING GROUPS; ONE-POT SYNTHESIS; COUPLING REACTIONS; BORON DIPYRROMETHENE; CARBOXYLIC-ACIDS; CLICK CHEMISTRY; PROPIOLIC ACID; ARYL IODIDES; GREEN LIGHT |
| Description | A controlled photorelease of alkynoic acids from the meso-methyl BODIPY photoremovable protecting group facilitates their subsequent efficient decarboxylation to give terminal alkynes for a Cu-I-catalyzed azide/ alkyne cycloaddition. The quantum efficiencies of the photochemical step and the kinetics of the click reaction step are reported. |
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