Biomonitoring práce s genotoxickými látkami a faktory ve zdravotnickém zařízení

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Title in English Biomonitoring of Work with Genotoxic Substances and Factors in a Cancer Treatment Facility
Authors

PETROVOVÁ Markéta MUSILOVÁ Petra SVOBODA Marek SELINGEROVÁ Iveta GONĚC Roman HRADSKÁ Hana KADLČÍKOVÁ Dita VOZDOVÁ Miluše BRHEL Petr RUBEŠ Jiří

Type Article in Proceedings
Conference XLII. ročník Brněnských onkologických dnů a XXXII. ročník Konference pro nelékařské zdravotnické pracovníky
MU Faculty or unit

Faculty of Medicine

Citation
WWW https://www.linkos.cz/files/klinicka-onkologie/437.pdf
Keywords preventive medicine; occupational exposure; cytostatic agens; chromosome aberrations; in situ hybridisation; fluorescence
Description Background: A long-term occupational exposure of healthcare staff to cytostatics and ionizing radiation is associated with a possible manifestation of their genotoxic, carcinogenic and teratogenic effects. Material and methods: A total number of 101 employees working with cytostatics or ionizing radiation were examined (some of them repeatedly) in a cancer treatment facility. The control group consisted of 118 persons excluded from the risk exposure. Fluorescence in situ hybridization with three pairs of whole-chromosomal probes and a pancrossomeric probe was used and the translocation frequency was determined. Results: The total number of chromosomal rearrangements of healthcare professionals and control group correlates with age. Taking into account the age dependence, an increased level of chromosomal reconstruction was found in the case of 11 individuals, 10 of which were female, working on the positions of pharmacist, general nurse, physician. Nine of those case involved the work with cytostatics. Five of these cases were re-examined two years later and the observed levels dropped to the control level. Conclusion: The results of biomonitoring should be evaluated on a group basis and individually, taking into account the personal history and possible non-professional effects on individuals – in particular those related to specific environmental measurement results. Background: A long-term occupational exposure of healthcare staff to cytostatics and ionizing radiation is associated with a possible manifestation of their genotoxic, carcinogenic and teratogenic effects. Material and methods: A total number of 101 employees working with cytostatics or ionizing radiation were examined (some of them repeatedly) in a cancer treatment facility. The control group consisted of 118 persons excluded from the risk exposure. Fluorescence in situ hybridization with three pairs of whole-chromosomal probes and a pancrossomeric probe was used and the translocation frequency was determined. Results: The total number of chromosomal rearrangements of healthcare professionals and control group correlates with age. Taking into account the age dependence, an increased level of chromosomal reconstruction was found in the case of 11 individuals, 10 of which were female, working on the positions of pharmacist, general nurse, physician. Nine of those case involved the work with cytostatics. Five of these cases were re-examined two years later and the observed levels dropped to the control level. Conclusion: The results of biomonitoring should be evaluated on a group basis and individually, taking into account the personal history and possible non-professional effects on individuals – in particular those related to specific environmental measurement results.