Symmetry Breaking for GATA-1/PU.1 Model
| Authors | |
|---|---|
| Year of publication | 2019 |
| Type | Article in Proceedings |
| Conference | Computational Methods in Systems Biology. CMSB 2019. Lecture Notes in Computer Science |
| MU Faculty or unit | |
| Citation | |
| Web | https://link.springer.com/chapter/10.1007/978-3-030-31304-3_27 |
| Doi | http://dx.doi.org/10.1007/978-3-030-31304-3_27 |
| Keywords | Bistability Symmetry breaking; Pitchfork bifurcation; GATA-1/PU.1 model; Biochemical switch |
| Description | This paper explains a substantial feature of symmetry breaking of dynamical systems that include bistability from the mathematical point of view to highlight important consequences of this phenomenon to biochemical and system biology studies since symmetry breaking as a bifurcation itself can serve as a source of branching. We take hematopoietic stem cells modeling as a particular case. |
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