Deficiency of Sprouty Proteins in Mice Resemble Ciliopathic Phenotype

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Authors

HRUBA E. KAVKOVA M. ZIKMUND T. HOVORAKOVA M. DALECKA L. BOSÁKOVÁ Michaela KREJČÍ Pavel BUCHTOVA M.

Year of publication 2019
Type Conference abstract
MU Faculty or unit

Faculty of Medicine

Citation
Description The Sprouty family of proteins is a highly conserved group of intracellular modulators of receptor tyrosine kinase signaling, including the fibroblast growth factor receptor (FGFR) pathway. There are four orthologs (Sprouty1-4) in mammals. During embryonic development and postnatal bone remodeling, tight regulation of FGFR signaling is essential in endochondral ossification and in bone and mineral homeostasis.
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