Neonatal CB1 receptor blockade differentially affects behavioural responses in normal and prenatally MAM exposed rats
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| Year of publication | 2019 |
| Type | Conference abstract |
| MU Faculty or unit | |
| Citation | |
| Description | c phenotype at adulthood. Delayed acquirement of early motor development milestones and significant deficits in motor function in individuals who subsequently develop schizophrenia have been a principal piece of evidence supporting this hypothesis. Animal models based on neurodevelopmental premise yield an advantage to assess alterations which could precede and/or contribute to the onset of the typical adult phenotype. Numerous studies support a dysregulation of the endocannabinoid system (ECS), both in terms of CB1 or CB2 receptors and endocannabinoid ligands anandamide or 2-arachidonoylglycerol (2-AG) seems to be involved in the pathophysiology of the psychosis as well. |
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