Non-antibiotic antibacterial peptides and proteins ofEscherichia coli: efficacy and potency of bacteriocins

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Authors

BOSÁK Juraj HRALA Matěj MICENKOVÁ Lenka ŠMAJS David

Year of publication 2021
Type Article in Periodical
Magazine / Source EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
MU Faculty or unit

Faculty of Medicine

Citation
Web https://www.tandfonline.com/doi/full/10.1080/14787210.2020.1816824
Doi http://dx.doi.org/10.1080/14787210.2020.1816824
Keywords Antimicrobials; bacteriocin; colicin; microcin; Escherichia; E; coli; probiotic; Shigella; virulence; diarrhea
Description Introduction The emergence and spread of antibiotic resistance among pathogenic bacteria drives the search for alternative antimicrobial therapies. Bacteriocins represent a potential alternative to antibiotic treatment. In contrast to antibiotics, bacteriocins are peptides or proteins that have relatively narrow spectra of antibacterial activities and are produced by a wide range of bacterial species. Bacteriocins ofEscherichia coliare historically classified as microcins and colicins, and, until now, more than 30 different bacteriocin types have been identified and characterized. Areas covered We performed bibliographical searches of online databases to review the literature regarding bacteriocins produced byE. coliwith respect to their occurrence, bacteriocin role in bacterial colonization and pathogenicity, and application of their antimicrobial effect. Expert opinion The potential use of bacteriocins for applications in human and animal medicine and the food industry includes (i) the use of bacteriocin-producing probiotic strains, (ii) recombinant production in plants and application in food, and (iii) application of purified bacteriocins.
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