Effect of Ag Nanoparticle Size on Ion Formation in Nanoparticle Assisted LDI MS

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Authors

PRYSIAZHNYI Vadym DYČKA Filip KRATOCHVIL Jiri STRANAK Vitezslav POPOK Vladimir

Year of publication 2020
Type Article in Periodical
Magazine / Source Applied Nano
MU Faculty or unit

Faculty of Science

Citation
Web link on the full articles
Doi http://dx.doi.org/10.3390/applnano1010002
Keywords silver nanoparticles; nano-PALDI MS; SALDI MS; laser desorption
Description Metal nanoparticles (NPs) were reported as an efficient matrix for detection of small molecules using laser desorption/ionization mass spectrometry. Their pronounced efficiency is mostly in desorption enhancement, while, in some cases, NPs can facilitate charge transfer to a molecule, which has been reported for alkali metals and silver. In this work, we present the study of the influence of Ag NP size on the laser desorption/ionization mass spectra of a model analyte, the molecule of riboflavin. The NPs were produced by magnetron sputtering-based gas aggregation in a vacuum and mass-filtered before the deposition on substrates. It was found that the utilization of smaller Ag NPs (below 15 nm in diameter) considerably enhanced the molecule desorption. In contrast, the laser irradiation of the samples with larger NPs led to the increased ablation of silver, resulting in [analyte + Ag]+ adduct formation.
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