Prostorová analýza recidiv glioblastomů v závislost na taktice adjuvantní radioterapie (stanovení cílových objemů dle RTOG vs. EORTC): představení akademické studie

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Title in English Spatial patterns of glioblastoma failure related to contouring strategy of adjuvant radiotherapy (RTOG vs. EORTC target volumes approach): Clinical trial introduction
Authors

HEJNOVÁ Renata HOLEŠOVSKÁ Alena POSPÍŠIL Petr LAKOMÝ Radek HYNKOVÁ Ludmila SELINGEROVÁ Iveta BELANOVÁ Renata STANDARA Michal JANČÁLEK Radim SMRČKA Martin FADRUS Pavel MÚČKOVÁ Katarína HENDRYCH Michal CHODÚR Tomáš ŠIFFELOVÁ Kamila ŠÁNA Jiří PROCHÁZKA Tomáš SLABÝ Ondřej ŠLAMPA Pavel KAZDA Tomáš

Year of publication 2020
Type Article in Periodical
Magazine / Source Klinická onkologie
MU Faculty or unit

Faculty of Medicine

Citation
Web https://www.linkos.cz/casopis-klinicka-onkologie/2020-09-15-supplementum-1/prostorova-analyza-recidiv-glioblastomu-v-zavislost-na-taktice-adjuvantni-radiot/
Doi http://dx.doi.org/10.14735/amko2020S20
Keywords glioblastoma; radiotherapy; contouring; patterns of failure; GlioART
Description Glioblastoma represents the most common and the most aggressive primary brain tumor in adults. Radiotherapy is indicated in almost all patients suffering with this disease. The importance of valid contouring (target volume definition) in radiotherapy of glioblastomas is currently increasing. The two basic contouring approaches in glioblastoma are the „American“ approach of the Radiation Therapy Oncology Group (RTOG contouring approach defining two target volumes) and the „European“ approach of the European Organization for Research and Treatment of Cancer (EORTC contouring approach with one target volume). Both mentioned approaches are considered standard of radiotherapy care. In daily radiotherapy practice, a specific contouring procedure is often chosen also according to the convention and tradition of the pertinent workplace. An important parameter in assessing the approach to contouring in radiotherapy is the evaluation of patterns of failure (PoF, spatial evaluation of subsequent relapses). Purpose: The GlioART, academic investigator initiated clinical study, compares the RTOG and EORTC approaches in a prospective setup, taking into account all parameters necessary for valid evaluation of progressions – definition of relapses, MR specification demonstrating progression, planned radiotherapy technique, glioblastoma molecular bio­logical characteristics, resection extent and localization of the original glioblastoma. The aim of this paper is to present the GlioART study and to discuss the associated topics associated with defining the target volumes in radiotherapy. Conclusion: The results of the GlioART trial may define recommendations influencing daily clinical practice in glioblastoma radiotherapy.
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