Klinický obraz spinální muskulární atrofie u dospělých pacientů

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Title in English Clinical manifestations of spinal muscular atrophy in adult patients
Authors

HORÁK Tomáš BEDNAŘÍK Josef HORÁKOVÁ Magda BOTIKOVÁ Daniela VOHÁŇKA Stanislav

Year of publication 2020
Type Article in Periodical
Magazine / Source Česká a slovenská neurologie a neurochirurgie
MU Faculty or unit

Faculty of Medicine

Citation
Web https://www.prolekare.cz/casopisy/ceska-slovenska-neurologie/2020-supplementum-2-2/klinicky-obraz-spinalni-muskularni-atrofie-u-dospelych-pacientu-125582
Doi http://dx.doi.org/10.48095/cccsnn20202S13
Keywords spinal muscular atrophy; adults; motor neuron; Kennedy‘s disease; differential diagnostics
Description Spinal muscular atrophy (SMA) is a phenotypically heterogeneous disease. Although the life expectancy and motor capability is significantly reduced in most patients, SMA types III and IV patients live to adulthood. In some cases, the association with a higher number of copies of the SMN2 gene and other protective factors are responsible for minimal motor impairment only. However, precise data on the prevalence of this disease in adult patients remain unknown. In the adult age, in addition to the classical 5q13 form of SMA, there are other rare genetic forms of late onset SMA with dominant disability in the lower limbs, which must be distinguished because of different clinical and therapeutic approaches. Since the development of SMA therapy, there has been a need for a clinical evaluation of therapeutic response and a definition of multidisciplinary care standards that have some specifics in adult SMA patients.
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