Design, synthesis and antiproliferative activity of newly designed derivatives of N-hydroxycinnamide
| Authors | |
|---|---|
| Year of publication | 2021 |
| Type | Appeared in Conference without Proceedings |
| MU Faculty or unit | |
| Citation | |
| Description | Histone acetylation is a process controlled by histone deacetylases (HDAC) and histone acetyltransferases (HAT), and it plays an essential role in the regulation of gene expression. HDACs are a family of enzymes that modulate the acetylation status of histones and non-histone proteins. Inhibitors of HDAC (HDACi), which form a complex with Zn2+ ion in the enzyme active site, are novel antiproliferative agents that induce tumor cell death, differentiation, and/or cell cycle arrest. |
| Related projects: |